Re: RX2800 sporadic disk I/O slowdowns

Followup on this.  I'm looking at one of Hein's presentations on RMS indexed files, tuning, etc.
Presuming the system has plenty of memory and per autogen its state of tune is pretty close to what autogen wants, is there any downside to setting a count of global buffers on the large indexed data files involved in this issue (the ones that show extended 'busy' channels in system analyzer)?  Can it cause any problems that would impact production?
We already tested setting a modest process RMS buffer count for indexed files on the accounts used for batch operations, and that seems to make a modest improvement in runtime and a significant reduction in direct I/Os.  Saved 3-4 minutes on a 32-34 minute runtime but DIOs dropped from ~5.1 million to ~4.3 million.
Unfortunately we still had two jobs run long, one over 7 hours so they killed it, the other about 4.5 hours but with the same reduced 4.3M DIO count.  So it helped in general but did not make a difference to the problem.  I don't expect the global buffers to fix the problem either but its worth testing for performance reasons.
Thanks