Re: Une réponse pro-inflammatoire soutenue

Le 31/03/2025 à 23:39, Duzz' a écrit :

Le 31/03/2025 à 21:18, Geo a écrit :

De Paul Aubrin, le 31/03/2025 :

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Mémoire épigénétique persistante de la *vaccination contre l'ARNm du SRAS-CoV-2* dans les macrophages dérivés de monocytes

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Mais non, le premier avril, c'est demain.

 Comme quoi, il est difficile de corriger une traduction foireuse, pour celui qui ne comprend déjà rien au texte d'origine.

Vous avez déjà beaucoup de difficultés à comprendre le français, néanmoins le résumé, dans sa langue originale, est ceci :
Abstract
Immune memory plays a critical role in the development of durable antimicrobial immune responses. How precisely mRNA vaccines train innate immune cells to shape protective host defense mechanisms remains unknown. Here we show that SARS-CoV-2 mRNA vaccination significantly establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters of human monocyte-derived macrophages, suggesting epigenetic memory. However, we found that two consecutive vaccinations were required for the persistence of H3K27ac, which matched with pro-inflammatory innate immune-associated transcriptional changes and antigen-mediated cytokine secretion. H3K27ac at promoter regions were preserved for six months and a single mRNA booster vaccine potently restored their levels and release of macrophage-derived cytokines. Interestingly, we found that H3K27ac at promoters is enriched for G-quadruplex DNA secondary structure-forming sequences in macrophage-derived nucleosome-depleted regions, linking epigenetic memory to nucleic acid structure. Collectively, these findings reveal that mRNA vaccines induce a highly dynamic and persistent training of innate immune cells enabling a sustained pro-inflammatory immune response.