Open AccessArticle
Determining Antiradical Capacity of Medicinal Plant Extract Individual
Constituents Using Post-Column Reaction Method
by Jarosław L. Przybył, Jan Stefaniak, Anna Jaroszewicz, Amanda
Gawrońska, Marcin Łapiński, Katarzyna Barbara Bączek and Zenon Węglarz
Int. J. Mol. Sci. 2024, 25(10), 5461;
https://doi.org/10.3390/ijms25105461 - 17 May 2024
Viewed by 570
Abstract The post-column reaction method enables the evaluation of the
antiradical capacity of individual components in a mixture by separating
the components using HPLC and measuring stable free radical (e.g.,
DPPH●) scavenging that occurs after the chromatography column. The
equipment typically consists of two [...] Read more.
(This article belongs to the Special Issue Natural Products and
Synthetic Compounds for Drug Development)
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24 pages, 4748 KiB
Open AccessArticle
The Different Composition of Coumarins and Antibacterial Activity of
Phlojodicarpus sibiricus and Phlojodicarpus villosus Root Extracts
by Maria T. Khandy, Valeria P. Grigorchuk, Anastasia K. Sofronova and
Tatiana Y. Gorpenchenko
Plants 2024, 13(5), 601;
https://doi.org/10.3390/plants13050601 - 22 Feb
2024
Viewed by 973
Abstract Phlojodicarpus sibiricus, a valuable endangered medicinal
plant, is a source of angular pyranocoumarins used in pharmacology. Due
to limited resource availability, other pyranocoumarin sources are
needed. In the present research, the chemical composition of a closely
related species, Phlojodicarpus villosus, was [...] Read more.
(This article belongs to the Special Issue Extraction Technologies,
Isolation, Separation, and Application of Phytochemicals Volume II)
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15 pages, 21439 KiB
Open AccessReview
Bergaptol, a Major Furocoumarin in Citrus: Pharmacological Properties
and Toxicity
by Pakkapong Phucharoenrak and Dunyaporn Trachootham
Molecules 2024, 29(3), 713;
https://doi.org/10.3390/molecules29030713 -
4 Feb 2024
Cited by 1 | Viewed by 1288
Abstract Bergaptol (5-hydroxypsoralen or 5-hydroxyfuranocoumarin) is a
naturally occurring furanocoumarin widely found in citrus fruits, which
has multiple health benefits. Nonetheless, no specific review articles
on bergaptol have been published. Compiling updated information on
bergaptol is crucial in guiding future research direction and
application. [...] Read more.
(This article belongs to the Special Issue Biological Activity of
Phenolics and Polyphenols in Nature Products)
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28 pages, 2974 KiB
Open AccessReview
Methoxyfuranocoumarins of Natural Origin–Updating Biological Activity
Research and Searching for New Directions—A Review
by Magdalena Bartnik
Curr. Issues Mol. Biol. 2024, 46(1), 856-883;
https://doi.org/10.3390/cimb46010055 - 19 Jan 2024
Cited by 1 | Viewed by 1085
Abstract Plant secondary metabolites, including furanocoumarins, have
attracted attention for decades as active molecules with therapeutic
potential, especially those occurring in a limited number of species as
evolutionarily specific and chemotaxonomically important. The most
famous methoxyfuranocoumarins (MFCs), bergapten, xanthotoxin,
isopimpinellin, phellopterin, byakangelicol, byakangelicin,
isobergapten, [...] Read more.
(This article belongs to the Special Issue Molecular Research in
Bioactivity of Natural Products)
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17 pages, 3184 KiB
Open AccessArticle
Furanocoumarins as Enhancers of Antitumor Potential of Sorafenib and
LY294002 toward Human Glioma Cells In Vitro
by Joanna Sumorek-Wiadro, Adrian Zając, Krystyna Skalicka-Woźniak,
Wojciech Rzeski and Joanna Jakubowicz-Gil
Int. J. Mol. Sci. 2024, 25(2), 759;
https://doi.org/10.3390/ijms25020759- 7 Jan 2024
Viewed by 954
Abstract Furanocoumarins are naturally occurring compounds in the plant
world, characterized by low molecular weight, simple chemical structure,
and high solubility in most organic solvents. Additionally, they have a
broad spectrum of activity, and their properties depend on the location
and type of attached [...] Read more.
(This article belongs to the Special Issue The Occurrence, Evolution and
Treatment of Glioblastoma)
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25 pages, 7395 KiB
Open AccessReview
A Review on the Morphology, Cultivation, Identification, Phytochemistry,
and Pharmacology of Kitagawia praeruptora (Dunn) Pimenov
by Qi Wang, Lulu Ding, Ruihong Wang and Zongsuo Liang
Molecules 2023, 28(24), 8153;
https://doi.org/10.3390/molecules28248153- 18 Dec 2023
Viewed by 979
Abstract Kitagawia praeruptora (Dunn) Pimenov, commonly known as Qianhu
in China, is a widely used folk Chinese herbal medicine. This article
reviews its botanical traits, ethnopharmacology, cultivation techniques,
identification, phytochemical compositions, and pharmacological effects.
Over 70 coumarin compounds, including simple coumarins, pyranocoumarins,
and furanocoumarins, [...] Read more.
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15 pages, 3819 KiB
Open AccessArticle
Notopterol Suppresses IL-17-Induced Proliferation and Invasion of A549
Lung Adenocarcinoma Cells via Modulation of STAT3, NF-κB, and AP-1
Activation
by Sirinada Inthanon, Pornngarm Dejkriengkraikul and Supachai Yodkeeree
Int. J. Mol. Sci. 2023, 24(20), 15057;
https://doi.org/10.3390/ijms242015057 - 11 Oct 2023
Cited by 3 | Viewed by 1374
Abstract Interleukine-17 is a proinflammatory cytokine that promotes
lung cancer growth and progression though the activation of the STAT3,
NF-κB, and AP-1 signaling pathways. Therefore, blocking the
IL-17-induced oncogenic pathway is a new strategy for the treatment of
lung cancer. Notopterol, a furanocoumarin, has [...] Read more.
(This article belongs to the Special Issue Latest Research on
Anti-cancer, Anti-inflammatory, and Antioxidation Active Substances)
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14 pages, 739 KiB
Open AccessArticle
Cytotoxic, Anti-Hemolytic, and Antioxidant Activities of Ruta
chalepensis L. (Rutaceae) Extract, Fractions, and Isolated Compounds
by Joel H. Elizondo-Luévano, Nancy E. Rodríguez-Garza, Aldo F.
Bazaldúa-Rodríguez, César I. Romo-Sáenz, Patricia Tamez-Guerra, María J.
Verde-Star, Ricardo Gomez-Flores and Ramiro Quintanilla-Licea
Plants 2023, 12(11), 2203;
https://doi.org/10.3390/plants12112203 - 2
Jun 2023
Cited by 2 | Viewed by 1807
Abstract Ruta chalepensis is an herb used to treat various ailments, and
its potential cytotoxic effects on different tumor cell lines have been
extensively studied. The present study aimed to evaluate the cytotoxic
activity of R. chalepensis methanol extract (RCME), sub-partitions
obtained from solvents [...] Read more.
(This article belongs to the Special Issue Bioactive Compounds in
Plants: Store House of Modern Drugs)
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18 pages, 12188 KiB
Open AccessArticle
Furanocoumarin Notopterol: Inhibition of Hepatocellular Carcinogenesis
through Suppression of Cancer Stemness Signaling and Induction of
Oxidative Stress-Associated Cell Death
by Ting-Yun Huang, Ching-Kuo Yang, Ming-Yao Chen, Vijesh Kumar Yadav,
Iat-Hang Fong, Chi-Tai Yeh and Yih-Giun Cherng
Nutrients 2023, 15(11), 2447;
https://doi.org/10.3390/nu15112447 - 24
May 2023
Cited by 4 | Viewed by 1963
Abstract Background: Hepatocellular carcinoma (HCC) remains an
aggressive malignancy with a poor prognosis and a leading cause of
cancer-related mortality globally. Cumulative evidence suggests critical
roles for endoplasmic reticulum (ER) stress and unfolded protein
response (UPR) in chronic liver diseases. However, the role of [...]
Read more.
(This article belongs to the Special Issue The Role of Dietary Bioactive
Compounds on Liver Cancer and Non-alcoholic Fatty Liver Disease)
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21 pages, 2647 KiB
Open AccessArticle
Hogweed Seed Oil: Physico–Chemical Characterization, LC-MS Profile, and
Neuroprotective Activity of Heracleum dissectum Nanosuspension
by Daniil N. Olennikov and Nadezhda K. Chirikova
Life 2023, 13(5), 1112;
https://doi.org/10.3390/life13051112 - 29 Apr
2023
Cited by 2 | Viewed by 1745
Abstract The seeds of dissected hogweed (Heracleum dissectum Ledeb.,
Apiaceae) are the source of hogweed oil (HSO), which is still
underexplored and requires careful chemical and biological studies. The
performed physico–chemical analysis of HSO elucidated basic physical
characteristics and revealed the presence of [...] Read more.
(This article belongs to the Special Issue Polyphenolic Compounds and
Their Nanoformulation: Metabolism and Impact on Human Health)
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18 pages, 1344 KiB
Open AccessArticle
Studies on the Accumulation of Secondary Metabolites and Evaluation of
Biological Activity of In Vitro Cultures of Ruta montana L. in Temporary
Immersion Bioreactors
by Agnieszka Szewczyk, Andreana Marino, Maria Fernanda Taviano, Lucia
Cambria, Federica Davì, Monika Trepa, Mariusz Grabowski and Natalizia
Miceli
Int. J. Mol. Sci. 2023, 24(8), 7045;
https://doi.org/10.3390/ijms24087045 - 11 Apr 2023
Cited by 3 | Viewed by 1884
Abstract The present work focuses on in vitro cultures of Ruta montana
L. in temporary immersion PlantformTM bioreactors. The main aim of the
study was to evaluate the effects of cultivation time (5 and 6 weeks)
and different concentrations (0.1–1.0 mg/L) of plant [...] Read more.
(This article belongs to the Special Issue Health Properties of Plant
Bioactive Compounds: Immune, Antioxidant and Metabolic Effects)
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36 pages, 3477 KiB
Open AccessArticle
Molecular Docking and Dynamics Simulation Studies Predict Potential
Anti-ADAR2 Inhibitors: Implications for the Treatment of Cancer,
Neurological, Immunological and Infectious Diseases
by Emmanuel Broni, Andrew Striegel, Carolyn Ashley, Patrick O. Sakyi,
Saqib Peracha, Miriam Velazquez, Kristeen Bebla, Monsheel Sodhi, Samuel
K. Kwofie, Adesanya Ademokunwa, Sufia Khan and Whelton A. Miller
Int. J. Mol. Sci. 2023, 24(7), 6795;
https://doi.org/10.3390/ijms24076795 - 5 Apr 2023
Cited by 8 | Viewed by 4003
Abstract Altered RNA editing has been linked to several
neurodevelopmental disorders, including autism spectrum disorder (ASD)
and intellectual disability, in addition to depression, schizophrenia,
some cancers, viral infections and autoimmune disorders. The human ADAR2
is a potential therapeutic target for managing these various disorders
[...] Read more.
(This article belongs to the Special Issue Recent Advances of Novel
Pharmaceutical Designs for Anti-cancer Therapies)
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17 pages, 5339 KiB
Open AccessArticle
Notopterol Ameliorates Hyperuricemia-Induced Cardiac Dysfunction in Mice
by Qian Wang, Dewei Peng, Bingyu Huang, Lintong Men, Tao Jiang, Shengqi
Huo, Moran Wang, Junyi Guo, Jiagao Lv and Li Lin
Pharmaceuticals 2023, 16(3), 361;
https://doi.org/10.3390/ph16030361 -
27 Feb 2023
Viewed by 1817
Abstract Notopterol is a naturally occurring furanocoumarin compound
found in the root of Notopterygium incisum. Hyperuricemia involves the
activation of chronic inflammation and leads to cardiac damage. Whether
notopterol has cardioprotective potential in hyperuricemia mice remains
elusive. The hyperuricemic mouse model was constructed by [...] Read
more.
(This article belongs to the Section Natural Products)
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12 pages, 2402 KiB
Open AccessArticle
Ruta chalepensis L. In Vitro Cultures as a Source of Bioactive
Furanocoumarins and Furoquinoline Alkaloids
by Agnieszka Szewczyk, Mariusz Grabowski and Dominika Zych
Life 2023, 13(2), 457;
https://doi.org/10.3390/life13020457 - 6 Feb 2023
Cited by 3 | Viewed by 1488
Abstract Recently, due to the decreasing areas of cultivation and
climate change, the use of biotechnological methods to obtain biomass,
which is a source of valuable bioactive metabolites, is becoming more
and more interesting. In this study, Ruta chalepensis in vitro cultures
were investigated [...] Read more.
(This article belongs to the Collection The Role of Bioactive Natural
Compounds in the Treatment of Diseases)
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18 pages, 5204 KiB
Open AccessArticle
Phytochemical Profile and In Vitro Antioxidant and Photobiological
Properties of Different Extracts from Prangos ferulacea Lindl.
by Mariangela Marrelli, Francesca Giordano, Maria Rosaria Perri,
Valentina Amodeo, Noemi Baldino, Carmine Lupia, Dimitar Uzunov, Vincenzo
Musolino, Filomena Conforti and Maria Luisa Panno
Antioxidants 2023, 12(2), 384;
https://doi.org/10.3390/antiox12020384 -
5 Feb 2023
Cited by 1 | Viewed by 1519
Abstract Interesting photobiological properties have been demonstrated
for some Cachrys species, including C. libanotis L., C. sicula L., and
C. pungens Jan. The present study was designed to assess the
photocytotoxic activity of Prangos ferulacea Lindl. (synonym of C.
ferulacea (L.) Calest.). This plant [...] Read more.
(This article belongs to the Special Issue Antioxidant and Biological
Properties of Plant Extracts II)
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31 pages, 1994 KiB
Open AccessSystematic Review
Cachrys L. Genus: A Comprehensive Review on Botany, Phytochemistry and
Biological Properties
by Vincenzo Musolino, Maria Rosaria Perri, Filomena Conforti, Micaela
Gliozzi, Mariangela Marrelli and Vincenzo Mollace
Plants 2023, 12(3), 565;
https://doi.org/10.3390/plants12030565 - 26 Jan
2023
Cited by 6 | Viewed by 1928
Abstract The Cachrys L. genus belongs to the Apiaceae family and it is
widely distributed in the Mediterranean basin, with plant species being
endemic to southern Europe, Asia, and northern Africa. Different
studies, focused on the phytochemical composition of Cachrys spp. and
the biological [...] Read more.
(This article belongs to the Collection Feature Review Papers in
Phytochemistry)
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18 pages, 3589 KiB
Open AccessReview
An Overview of Potential Natural Photosensitizers in Cancer Photodynamic
Therapy
by Bushra Aziz, Iffat Aziz, Ahmat Khurshid, Ehsan Raoufi, Fahime Nasr
Esfahani, Zahra Jalilian, M. R. Mozafari, Elham Taghavi and Masroor
Ikram
Biomedicines 2023, 11(1), 224;
https://doi.org/10.3390/biomedicines11010224 - 16 Jan 2023
Cited by 22 | Viewed by 4021
Abstract Cancer is one of the main causes of death worldwide. There are
several different types of cancer recognized thus far, which can be
treated by different approaches including surgery, radiotherapy,
chemotherapy or a combination thereof. However, these approaches have
certain drawbacks and limitations. [...] Read more.
(This article belongs to the Section Molecular and Translational
Medicine)
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18 pages, 1188 KiB
Open AccessArticle
The Influence of Exogenous Phenylalanine on the Accumulation of
Secondary Metabolites in Agitated Shoot Cultures of Ruta graveolens L.
by Agnieszka Szewczyk, Wojciech Paździora and Halina Ekiert
Molecules 2023, 28(2), 727;
https://doi.org/10.3390/molecules28020727 -
11 Jan 2023
Cited by 6 | Viewed by 1445
Abstract This study aimed to examine the influence of the addition of a
precursor (phenylalanine) on the accumulation of secondary metabolites
in agitated shoot cultures of Ruta graveolens. Cultures were grown on
Linsmaier and Skoog (LS) medium, with plant growth regulators (0.1 mg/L
α-naphthaleneacetic [...] Read more.
(This article belongs to the Special Issue Phenolic/Polyphenolic Profile
and Biological Activities of Natural Products)
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25 pages, 923 KiB
Open AccessReview
Phytochemical Constituents, Folk Medicinal Uses, and Biological
Activities of Genus Angelica: A Review
by Gaber El-Saber Batiha, Hazem M. Shaheen, Esraa A. Elhawary, Nada M.
Mostafa, Omayma A. Eldahshan and Jean-Marc Sabatier
Molecules 2023, 28(1), 267;
https://doi.org/10.3390/molecules28010267 -
28 Dec 2022
Cited by 13 | Viewed by 4106
Abstract Genus Angelica is one of the widely distributed and well-known
genera of family Umbelliferae. It is utilized mainly by Chinese and
Korean populations especially in their folk medicine. Angelica comprises
a lot of medicinally important phytoconstituents such as coumarins,
furanocoumarins, flavonoids, essential oils, [...] Read more.
(This article belongs to the Special Issue Phytochemistry and
Bioactivity of the Natural Products)
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21 pages, 2203 KiB
Open AccessReview
Insights into Antiviral Properties and Molecular Mechanisms of
Non-Flavonoid Polyphenols against Human Herpesviruses
by Sherif T. S. Hassan, Miroslava Šudomová, Alena Mazurakova and Peter
Kubatka
Int. J. Mol. Sci. 2022, 23(22), 13891;
https://doi.org/10.3390/ijms232213891 - 11 Nov 2022
Cited by 10 | Viewed by 2940
Abstract Herpesviruses are one of the most contagious DNA viruses that
threaten human health, causing severe diseases, including, but not
limited to, certain types of cancer and neurological complications. The
overuse and misuse of anti-herpesvirus drugs are key factors leading to
drug resistance. Therefore, [...] Read more.
(This article belongs to the Special Issue Molecular Medicine
Applications in Infectious Diseases: Latest Innovations)
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13 pages, 2141 KiB
Open AccessArticle
Cachrys spp. from Southern Italy: Phytochemical Characterization and
JAK/STAT Signaling Pathway Inhibition
by Maria Rosaria Perri, Michele Pellegrino, Stefano Aquaro, Fabiola
Cavaliere, Carmine Lupia, Dimitar Uzunov, Mariangela Marrelli, Filomena
Conforti and Giancarlo Statti
Plants 2022, 11(21), 2913;
https://doi.org/10.3390/plants11212913 - 29
Oct 2022
Cited by 5 | Viewed by 1384
Abstract Different phytochemical compounds have been demonstrated to
modulate the JAK/STAT signaling pathway. Here, three Cachrys species
from Southern Italy were investigated for both the phytochemical profile
and the potential anti-inflammatory properties. The aerial parts were
extracted with methanol through Naviglio Extractor®, [...] Read more.
(This article belongs to the Collection Bioactive Compounds in Plants)
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20 pages, 1266 KiB
Open AccessArticle
Challenges in the Heterologous Production of Furanocoumarins in
Escherichia coli
by Joana L. Rodrigues, Daniela Gomes and Lígia R. Rodrigues
Molecules 2022, 27(21), 7230;
https://doi.org/10.3390/molecules27217230- 25 Oct 2022
Cited by 7 | Viewed by 1823
Abstract Coumarins and furanocoumarins are plant secondary metabolites
with known biological activities. As they are present in low amounts in
plants, their heterologous production emerged as a more sustainable and
efficient approach to plant extraction. Although coumarins biosynthesis
has been positively established, furanocoumarin biosynthesis [...] Read
more.
(This article belongs to the Special Issue Coumarin and Its Derivatives
II)
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12 pages, 1985 KiB
Open AccessArticle
Ameliorative Effect of Imperatorin on Dermatophagoides
pteronyssinus-Induced Allergic Asthma by Suppressing the Th2 Response in
Mice
by Chia-Chen Hsieh, Yan-Yan Ng, Wei-Sung Li, Chung-Yuh Tzeng, Tsai-Yi
Hsu, Wan-Hsiang Huang and Jen-Chieh Tsai
Molecules 2022, 27(20), 7028;
https://doi.org/10.3390/molecules27207028- 18 Oct 2022
Cited by 2 | Viewed by 1528
Abstract Imperatorin is a furanocoumarin derivative and an effective
ingredient in several Chinese medicinal herbs. It has favorable
expectorant, analgesic, and anti-inflammatory effects. In this study, we
investigated whether imperatorin has protective effects against
Dermatophagoides pteronyssinus (Der p)-induced asthma in mice. Lung
[...] Read more.
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17 pages, 1797 KiB
Open AccessArticle
Potential Biochemical Pesticide—Synthesis of Neofuranocoumarin and
Inhibition the Proliferation of Spodoptera frugiperda Cells through
Activating the Mitochondrial Pathway
by Xuehua Shao, Zhuhong Zhang, Xuhong Qian, Lanying Wang, Yunfei Zhang
and Yanping Luo
Toxins 2022, 14(10), 677;
https://doi.org/10.3390/toxins14100677 - 29
Sep 2022
Cited by 2 | Viewed by 1757
Abstract Furanocoumarins, the secondary metabolites of plants, are
considered to be natural insecticides and fungicides because they
prevent the invasion of plant pathogenic microorganisms and the
predation of herbivorous insects. In this study, novel
2-arylfuranocoumarin derivatives were designed to synthesize by
condensation, esterification, bromination, [...] Read more.
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17 pages, 1041 KiB
Open AccessArticle
Authentication of Citrus spp. Cold-Pressed Essential Oils by Their
Oxygenated Heterocyclic Components
by Noura S. Dosoky, Prabodh Satyal and William N. Setzer
Molecules 2022, 27(19), 6277;
https://doi.org/10.3390/molecules27196277- 23 Sep 2022
Cited by 6 | Viewed by 2012
Abstract Citrus essential oils are routinely adulterated because of the
lack of regulations or reliable authentication methods. Unfortunately,
the relatively simple chemical makeup and the tremendous price
variations among Citrus varieties encouraged the interspecies
adulteration of citrus oils. In this study, a sensitive UPLC-MS/MS [...]
Read more.
(This article belongs to the Special Issue Application of Spectroscopy
and Chemometrics for Authentication of Foods and Drugs)
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21 pages, 4827 KiB
Open AccessArticle
6-Formyl Umbelliferone, a Furanocoumarin from Angelica decursiva L.,
Inhibits Key Diabetes-Related Enzymes and Advanced Glycation End-Product
Formation
by Md Yousof Ali, Gerald W. Zamponi, Su Hui Seong, Hyun Ah Jung and Jae
Sue Choi
Molecules 2022, 27(17), 5720;
https://doi.org/10.3390/molecules27175720- 5 Sep 2022
Cited by 5 | Viewed by 1852
Abstract Over the years, great attention has been paid to coumarin
derivatives, a set of versatile molecules that exhibit a wide variety of
biological activities and have few toxic side effects. In this study, we
investigated the antidiabetic potential of 6-formyl umbelliferone
(6-FU), a [...] Read more.
(This article belongs to the Section Medicinal Chemistry)
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20 pages, 4084 KiB
Open AccessArticle
Improvement in Solubility–Permeability Interplay of Psoralens from
Brosimum gaudichaudii Plant Extract upon Complexation with
Hydroxypropyl-β-cyclodextrin
by Rúbia Darc Machado, Júlio C. G. Silva, Luís A. D. Silva, Gerlon de A.
R. Oliveira, Luciano M. Lião, Eliana M. Lima, Mariana C. de Morais,
Edemilson C. da Conceição and Kênnia R. Rezende
Molecules 2022, 27(14), 4580;
https://doi.org/10.3390/molecules27144580- 19 Jul 2022
Cited by 1 | Viewed by 1799
Abstract Psoralen (PSO) and 5-methoxypsoralen (5-MOP) are widely used
drugs in oral photochemotherapy against vitiligo and major bioactive
components of root bark extract of Brosimum gaudichaudii Trécul (EBGT),
previously standardized by LC-MS. However, the exceptionally low water
solubility of these psoralens can cause incomplete [...] Read more.
(This article belongs to the Special Issue Natural Bioactive Compounds
and Human Health)
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14 pages, 1707 KiB
Open AccessArticle
Different Seasonal Collections of Ficus carica L. Leaves Diversely
Modulate Lipid Metabolism and Adipogenesis in 3T3-L1 Adipocytes
by Mariachiara Pucci, Manuela Mandrone, Ilaria Chiocchio, Eileen Mac
Sweeney, Emanuela Tirelli, Daniela Uberti, Maurizio Memo, Ferruccio
Poli, Andrea Mastinu and Giulia Abate
Nutrients 2022, 14(14), 2833;
https://doi.org/10.3390/nu14142833 - 10
Jul 2022
Cited by 8 | Viewed by 2959
Abstract Due to the high prevalence of obesity and type 2 diabetes,
adipogenesis dysfunction and metabolic disorders are common features in
the elderly population. Thus, the identification of novel compounds with
anti-adipogenic and lipolytic effects is highly desirable to reduce
diabetes complications. Plants represent [...] Read more.
(This article belongs to the Special Issue Functional Properties of
Natural Products and Human Health)
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10 pages, 1185 KiB
Open AccessArticle
Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in
Rats after Single Intravenous and Oral Administration
by Ming-Cong Zheng, Wen-Ting Tang, Lu-Lu Yu, Xun-Jia Qian, Jie Ren,
Jie-Jia Li, Wei-Wei Rong, Jun-Xu Li and Qing Zhu
Molecules 2022, 27(11), 3570;
https://doi.org/10.3390/molecules27113570- 2 Jun 2022
Cited by 5 | Viewed by 2230
Abstract Oxypeucedanin, a furanocoumarin extracted from many traditional
Chinese herbal medicines, has a variety of pharmacological effects.
However, the independent pharmacokinetic characteristics and
bioavailability of this compound remains elusive. In this study, a
rapid, sensitive, and selective method using ultra-high performance
liquid chromatography–tandem mass [...] Read more.
(This article belongs to the Topic Advances in Natural Products from
Plants and Associated Microbes)
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30 pages, 4540 KiB
Open AccessReview
Anti-Inflammatory and Antioxidant Chinese Herbal Medicines: Links
between Traditional Characters and the Skin Lipoperoxidation “Western”
Model
by Jose M. Prieto and Guillermo R. Schinella
Antioxidants 2022, 11(4), 611;
https://doi.org/10.3390/antiox11040611 -
23 Mar 2022
Cited by 7 | Viewed by 4772
Abstract The relationship between lipid peroxidation and inflammation
has been accepted as a paradigm in the field of topical inflammation.
The underlying biochemical mechanisms may be summarised as unspecific
oxidative damage followed by specific oxidative processes as the physio
pathological response in skin tissues. [...] Read more.
(This article belongs to the Special Issue Antioxidant,
Anti-inflammatory and Anticancer Activities of the Natural Products)
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16 pages, 2239 KiB
Open AccessArticle
Phytochemical Characterization, and Antioxidant and Antimicrobial
Properties of Agitated Cultures of Three Rue Species: Ruta chalepensis,
Ruta corsica, and Ruta graveolens
by Agnieszka Szewczyk, Andreana Marino, Jessica Molinari, Halina Ekiert
and Natalizia Miceli
Antioxidants 2022, 11(3), 592;
https://doi.org/10.3390/antiox11030592 -
20 Mar 2022
Cited by 18 | Viewed by 3508
Abstract The in vitro cultures of the following three species of the
genus Ruta were investigated: R. chalepensis, R. corsica, and R.
graveolens. The dynamics of biomass growth and accumulation of secondary
metabolites in the 3-, 4-, 5-, 6-, and 7-week [...] Read more.
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19 pages, 2561 KiB
Open AccessReview
Some Natural Photosensitizers and Their Medicinal Properties for Use in
Photodynamic Therapy
by Tomasz Piotr Kubrak, Przemysław Kołodziej, Jan Sawicki, Anna Mazur,
Katarzyna Koziorowska and David Aebisher
Molecules 2022, 27(4), 1192;
https://doi.org/10.3390/molecules27041192 -
10 Feb 2022
Cited by 47 | Viewed by 6521
Abstract Despite significant advances in early diagnosis and treatment,
cancer is one of the leading causes of death. Photodynamic therapy (PDT)
is a therapy for the treatment of many diseases, including cancer. This
therapy uses a combination of a photosensitizer (PS), light irradiation
of [...] Read more.
(This article belongs to the Special Issue Photosensitizer: Design,
Characteriazation and Application)
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14 pages, 1654 KiB
Open AccessArticle
Imperatorin Influences Depressive-like Behaviors: A Preclinical Study on
Behavioral and Neurochemical Sex Differences
by Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina
Dalla, Nikolaos Kokras, Krystyna Skalicka-Woźniak and Barbara Budzyńska
Molecules 2022, 27(4), 1179;
https://doi.org/10.3390/molecules27041179 -
10 Feb 2022
Cited by 5 | Viewed by 1876
Abstract Imperatorin, a naturally derived furanocoumarin, exerts
promising neuropharmacological properties. Therefore, it might be
applicable in the treatment of brain diseases such as depression. In the
present project, we aimed to investigate the sex-dependent effects of
imperatorin (1, 5, and 10 mg/kg) on behavior [...] Read more.
(This article belongs to the Special Issue Isolation and Structure
Determination of Bioactive Natural Products)
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16 pages, 2804 KiB
Open AccessArticle
Potential Anticancer Activity of the Furanocoumarin Derivative
Xanthotoxin Isolated from Ammi majus L. Fruits: In Vitro and In Silico
Studies
by Marwa Y. Issa, Mohamed F. Elshal, Noha Fathallah, Mostafa A.
Abdelkawy, Mokhtar Bishr, Osama Salama and Yasmin S. Abulfadl
Molecules 2022, 27(3), 943;
https://doi.org/10.3390/molecules27030943 -
29 Jan 2022
Cited by 9 | Viewed by 3797
Abstract Ammi majus L., an indigenous plant in Egypt, is widely used in
traditional medicine due to its various pharmacological properties. We
aimed to evaluate the anticancer properties of Ammi majus fruit methanol
extract (AME) against liver cancer and to elucidate the active
compound(s) [...] Read more.
(This article belongs to the Special Issue Extraction, Separation and
Identification of Compounds from Natural Sources)
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14 pages, 16489 KiB
Open AccessArticle
Flavonoids and Limonoids Profiles Variation in Leaves from Mandarin
Cultivars and Its Relationship with Alternate Bearing
by Cecilia Rodríguez Ceraolo, Valeria Vázquez, Ignacio Migues, María
Verónica Cesio, Fernando Rivas and Horacio Heinzen
Agronomy 2022, 12(1), 121;
https://doi.org/10.3390/agronomy12010121 - 4
Jan 2022
Cited by 4 | Viewed by 1940
Abstract Alternate bearing in citrus trees has been extensively studied
as a key feature for citrus growers. Although the genetic and the
biochemical process occurring during alternate bearing has been studied
extensively, there is a lack of information identifying the presence of
metabolic indicators [...] Read more.
(This article belongs to the Special Issue Advances in Citrus Breeding,
Genetics, Physiology and Horticultural Management)
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12 pages, 765 KiB
Open AccessArticle
Retrieval of High Added Value Natural Bioactive Coumarins from Mandarin
Juice-Making Industrial Byproduct
by Eleni D. Myrtsi, Apostolis Angelis, Sofia D. Koulocheri, Sofia
Mitakou and Serkos A. Haroutounian
Molecules 2021, 26(24), 7527;
https://doi.org/10.3390/molecules26247527- 12 Dec 2021
Cited by 3 | Viewed by 2304
Abstract Cold pressed essential oil (CPEO) of mandarin (Citrus
reticulata Blanco), a by-product of the juice-making industrial process
known to contain large amounts of polymethoxyflavones, was exploited for
its content in high added value natural coumarins. The study herein
afforded a method referring [...] Read more.
(This article belongs to the Special Issue Extraction, Characterization,
and Potential Applications of Bioactive Molecules from Natural Sources
II)
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13 pages, 1436 KiB
Open AccessArticle
An Efficient Ionic Liquid-Mediated Extraction and Enrichment of
Isoimperatorin from Ostericum koreanum (Max.) Kitagawa
by Alice Nguvoko Kiyonga, Gyu Hwan Park, Hyun Su Kim, Young-Ger Suh, Tae
Kon Kim and Kiwon Jung
Molecules 2021, 26(21), 6555;
https://doi.org/10.3390/molecules26216555- 29 Oct 2021
Cited by 3 | Viewed by 1650
Abstract Ionic liquids (ILs) have attracted significant interest because
of their desirable properties. These characteristics have improved their
application to overcome the shortcomings of conventional separation
techniques for phytochemicals. In this study, several ILs were
investigated for their capacity to extract isoimperatorin, a bioactive
[...] Read more.
(This article belongs to the Section Green Chemistry)
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24 pages, 1467 KiB
Open AccessReview
Oxypeucedanin: Chemotaxonomy, Isolation, and Bioactivities
by Javad Mottaghipisheh
Plants 2021, 10(8), 1577;
https://doi.org/10.3390/plants10081577 - 30
Jul 2021
Cited by 12 | Viewed by 4994
Abstract The present review comprehensively gathered phytochemical,
bioactivity, and pharmacokinetic reports on a linear furanocoumarin,
namely oxypeucedanin. Oxypeucedanin (OP), which structurally contains an
epoxide ring, has been majorly isolated from ethyl acetate-soluble
partitions of several genera, particularly Angelica, Ferulago, and
Prangos of [...] Read more.
(This article belongs to the Special Issue Trends in Plants
Phytochemistry and Bioactivity Analysis)
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11 pages, 8299 KiB
Open AccessArticle
Furanocoumarins from Ruta chalepensis with Amebicide Activity
by Aldo Fabio Bazaldúa-Rodríguez, Ramiro Quintanilla-Licea, María Julia
Verde-Star, Magda Elizabeth Hernández-García, Javier Vargas-Villarreal
and Jesús Norberto Garza-González
Molecules 2021, 26(12), 3684;
https://doi.org/10.3390/molecules26123684- 16 Jun 2021
Cited by 10 | Viewed by 2317
Abstract Entamoeba histolytica (protozoan; family Endomoebidae) is the
cause of amoebiasis, a disease related to high morbidity and mortality.
Nowadays, this illness is considered a significant public health issue
in developing countries. In addition, parasite resistance to
conventional medicinal treatment has increased in recent [...] Read
more.
(This article belongs to the Special Issue Biologically Active Small
Molecules Inspired by Plant Secondary Metabolites)
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13 pages, 1831 KiB
Open AccessArticle
High Temperature Alters Secondary Metabolites and Photosynthetic
Efficiency in Heracleum sosnowskyi
by Anna Rysiak, Sławomir Dresler, Agnieszka Hanaka, Barbara
Hawrylak-Nowak, Maciej Strzemski, Jozef Kováčik, Ireneusz Sowa, Michał
Latalski and Magdalena Wójciak
Int. J. Mol. Sci. 2021, 22(9), 4756;
https://doi.org/10.3390/ijms22094756 - 30 Apr 2021
Cited by 18 | Viewed by 2485
Abstract Due to global warming, invasive species have spread across the
world. We therefore studied the impact of short-term (1 day or 2 days)
and longer (7 days) heat stress on photosynthesis and secondary
metabolites in Heracleum sosnowskyi, one of the important invasive [...]
Read more.
(This article belongs to the Special Issue Animal and Plant Cell–Tissue,
Organ Specialization and Function: Investigational, Experimental and
Medical Aspects 2.0)
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12 pages, 583 KiB
Open AccessFeature PaperReview
Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic
Potential
by Lutfun Nahar, Shaymaa Al-Majmaie, Afaf Al-Groshi, Azhar Rasul and
Satyajit D. Sarker
Molecules 2021, 26(6), 1609;
https://doi.org/10.3390/molecules26061609 -
14 Mar 2021
Cited by 13 | Viewed by 3165
Abstract Dihydrofuranocoumarin, chalepin (1) and furanocoumarin,
chalepensin (2) are 3-prenylated bioactive coumarins, first isolated
from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae)
but also distributed in various species of the genera Boenminghausenia,
Clausena and Ruta. The [...] Read more.
(This article belongs to the Special Issue Coumarin and Its Derivatives)
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14 pages, 10752 KiB
Open AccessArticle
Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone
on LPS-Induced Amnesia in Mice
by Łukasz Kurach, Sylwia Kulczycka-Mamona, Joanna Kowalczyk, Krystyna
Skalicka-Woźniak, Anna Boguszewska-Czubara, Nesrine El Sayed, Mitat
Osmani, Karol Iwaniak and Barbara Budzyńska
Int. J. Mol. Sci. 2021, 22(4), 1779;
https://doi.org/10.3390/ijms22041779 - 10 Feb 2021
Cited by 12 | Viewed by 2664
Abstract Neuroinflammation plays an essential role in the pathogenesis
of neurodegenerative diseases such as Alzheimer’s disease. Although
coumarins have been shown to improve cognitive function in animal models
and exert anti-inflammatory effects in cell cultures, the exact
mechanism of their neuroprotective effects has not [...] Read more.
(This article belongs to the Section Molecular Pharmacology)
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13 pages, 2168 KiB
Open AccessArticle
Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and
Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma
Cells
by Mariangela Marrelli, Maria Rosaria Perri, Valentina Amodeo, Francesca
Giordano, Giancarlo A. Statti, Maria Luisa Panno and Filomena Conforti
Plants 2021, 10(1), 123;
https://doi.org/10.3390/plants10010123 - 8 Jan
2021
Cited by 13 | Viewed by 2104
Abstract Photochemotherapy is one of the most interesting current
therapeutic approaches for the treatment of melanoma. Different classes
of naturally occurring phytochemicals demonstrated interesting
photoactive properties. The aim of this study was to evaluate the
photocytotoxic potential of two Cachrys species from Southern Italy:
[...] Read more.
(This article belongs to the Collection Medicinal Plants: New Advances
in Phytochemicals and Their Health Benefits)
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468 KiB
Open AccessProceeding Paper
Cachrys libanotis L. Extracts: Photocytotoxic Effects on UVA-Irradiated
Human Melanoma Cells
by Mariangela Marrelli, Francesca Giordano, Valentina Amodeo, Maria
Rosaria Perri, Giancarlo Statti, Maria Luisa Panno and Filomena Conforti
Biol. Life Sci. Forum 2021, 4(1), 54;
https://doi.org/10.3390/IECPS2020-08574 - 30 Nov 2020
Viewed by 796
Abstract Melanoma is the most aggressive form of skin cancer.
Photochemotherapy, combining the action of a light source and a chemical
photosensitizer, is one of the most interesting current therapeutic
approaches. Plants represent a rich source of photoactive compounds, and
furanocoumarins are some of [...] Read more.
(This article belongs to the Proceedings of The 1st International
Electronic Conference on Plant Science)
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22 pages, 2633 KiB
Open AccessReview
Role of Photoactive Phytocompounds in Photodynamic Therapy of Cancer
by Kasipandi Muniyandi, Blassan George, Thangaraj Parimelazhagan and
Heidi Abrahamse
Molecules 2020, 25(18), 4102;
https://doi.org/10.3390/molecules25184102- 8 Sep 2020
Cited by 49 | Viewed by 4689
Abstract Cancer is one of the greatest life-threatening diseases
conventionally treated using chemo- and radio-therapy. Photodynamic
therapy (PDT) is a promising approach to eradicate different types of
cancers. PDT requires the administration of photosensitisers (PSs) and
photoactivation using a specific wavelength of light in [...] Read more.
(This article belongs to the Special Issue Anticancer Properties of
Natural and Derivative Products)
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20 pages, 3833 KiB
Open AccessReview
Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic
Aspects
by Salman Ahmed, Haroon Khan, Michael Aschner, Hamed Mirzae, Esra Küpeli
Akkol and Raffaele Capasso
Int. J. Mol. Sci. 2020, 21(16), 5622;
https://doi.org/10.3390/ijms21165622 - 6 Aug 2020
Cited by 120 | Viewed by 5765
Abstract Cancer is one of the most extreme medical conditions in both
developing and developed countries around the world, causing millions of
deaths each year. Chemotherapy and/or radiotherapy are key for treatment
approaches, but both have numerous adverse health effects. Furthermore,
the resistance of [...] Read more.
(This article belongs to the Special Issue Biological Properties of
Medicinal Plants)
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23 pages, 1398 KiB
Open AccessReview
Ducrosia spp., Rare Plants with Promising Phytochemical and
Pharmacological Characteristics: An Updated Review
by Javad Mottaghipisheh, Anahita Boveiri Dehsheikh, Mohammad Mahmoodi
Sourestani, Tivadar Kiss, Judit Hohmann and Dezső Csupor
Pharmaceuticals 2020, 13(8), 175;
https://doi.org/10.3390/ph13080175 -
31 Jul 2020
Cited by 10 | Viewed by 4027
Abstract The rare genus Ducrosia (Apiaceae family) consists of six
species, which are mainly native to Asia, specifically to Iran and Iraq.
The aerial parts of D. anethifolia, as the most common species, have
been traditionally consumed to relieve headache, backache and colic
pain, [...] Read more.
(This article belongs to the Special Issue Medicinal Plants 2020)
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20 pages, 7750 KiB
Open AccessArticle
The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin
Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal
Structure and DFT Studies
by Miriam Rossi, Sandjida Aktar, Marissa Davis, Emily Hefter Feuss,
Samara Roman-Holba, Kelly Wen, Christopher Gahn and Francesco Caruso
Molecules 2020, 25(14), 3158;
https://doi.org/10.3390/molecules25143158- 10 Jul 2020
Cited by 8 | Viewed by 3516
Abstract Coumarins are plant-derived secondary metabolites. The crystal
structure of three coumarins—bergamottin, osthole and fraxidin—are
described and we analyze intermolecular interactions and their role in
crystal formation. Bergamottin is a furanocoumarin found in citrus
plants, which is a strong inhibitor of the principal human [...] Read
more.
(This article belongs to the Special Issue Bioactive Natural Compounds
and Their Mechanisms of Action)
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11 pages, 2732 KiB
Open AccessArticle
Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of
Neocryptodiscus papillaris with Cytotoxic Activity on Renal Cancer Cells
by Fatma Tosun, Feyyaz Mıhoğlugil, John A. A. Beutler, Esra Eroğlu Özkan
and Mahmut Miski
Molecules 2020, 25(13), 3040;
https://doi.org/10.3390/molecules25133040- 3 Jul 2020
Cited by 9 | Viewed by 2412
Abstract Several simple and prenylated coumarin derivatives were
isolated from the dichloromethane extract of the root of Neocryptodiscus
papillaris based on moderate cytotoxic activity of the extract in
COLO205, KM12 and MCF7 cancer cells. While the major prenylated
furanocoumarin derivatives and osthol isolated from [...] Read more.
(This article belongs to the Section Natural Products Chemistry)
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11 pages, 3270 KiB
Open AccessCommunication
Physicochemical Investigation of Psoralen Binding to Double Stranded DNA
through Electroanalytical and Cheminformatic Approaches
by Douglas Vieira Thomaz, Matheus Gabriel de Oliveira, Edson Silvio
Batista Rodrigues, Vinicius Barreto da Silva and Pierre Alexandre dos
Santos
Pharmaceuticals 2020, 13(6), 108;
https://doi.org/10.3390/ph13060108 -
28 May 2020
Cited by 6 | Viewed by 3169
Abstract This work showcased the first physicochemical investigation of
psoralen (PSO) binding to double stranded DNA (dsDNA) through
electroanalytical methods. Results evidenced that PSO presents one
non-reversible anodic peak at electric potential (Epa) ≈ 1.42 V, which
is associated with its [...] Read more.
(This article belongs to the Special Issue Selected Papers from the 5th
International Electronic Conference on Medicinal Chemistry)
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21 pages, 4152 KiB
Open AccessArticle
A Biochemometric Approach for the Identification of In Vitro
Anti-Inflammatory Constituents in Masterwort
by Julia Zwirchmayr, Ulrike Grienke, Scarlet Hummelbrunner, Jacqueline
Seigner, Rainer de Martin, Verena M. Dirsch and Judith M. Rollinger
Biomolecules 2020, 10(5), 679;
https://doi.org/10.3390/biom10050679 - 28
Apr 2020
Cited by 15 | Viewed by 3476
Abstract Peucedanum ostruthium (L.) Koch, commonly known as masterwort,
has a longstanding history as herbal remedy in the Alpine region of
Austria, where the roots and rhizomes are traditionally used to treat
disorders of the gastrointestinal and respiratory tract. Based on a
significant NF-κB [...] Read more.
(This article belongs to the Special Issue Phytochemical Omics in
Medicinal Plants)
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17 pages, 3840 KiB
Open AccessArticle
Imperatorin as a Promising Chemotherapeutic Agent against Human Larynx
Cancer and Rhabdomyosarcoma Cells
by Aneta Grabarska, Krystyna Skalicka-Woźniak, Michał Kiełbus, Magdalena
Dmoszyńska-Graniczka, Paulina Miziak, Justyna Szumiło, Ewa Nowosadzka,
Krystyna Kowalczuk, Sherief Khalifa, Jolanta Smok-Kalwat, Janusz Klatka,
Krzysztof Kupisz, Krzysztof Polberg, Adolfo Rivero-Müller and Andrzej
Stepulak
Molecules 2020, 25(9), 2046;
https://doi.org/10.3390/molecules25092046 -
28 Apr 2020
Cited by 16 | Viewed by 3299
Abstract Naturally occurring coumarins are bioactive compounds widely
used in Asian traditional medicine. They have been shown to inhibit
proliferation, induce apoptosis, and/or enhance the cytotoxicity of
currently used drugs against a variety of cancer cell types. The aim of
our study was to [...] Read more.
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17 pages, 2699 KiB
Open AccessArticle
Bio-Guided Fractionation of Prenylated Benzaldehyde Derivatives as
Potent Antimicrobial and Antibiofilm from Ammi majus L.
Fruits-Associated Aspergillus amstelodami
by Noha Fathallah, Marwa M. Raafat, Marwa Y. Issa, Marwa M. Abdel-Aziz,
Mokhtar Bishr, Mostafa A. Abdelkawy and Osama Salama
Molecules 2019, 24(22), 4118;
https://doi.org/10.3390/molecules24224118- 14 Nov 2019
Cited by 37 | Viewed by 3723
Abstract Ammi majus L.; Family Apiaceae; is a plant indigenous to Egypt.
Its fruits contain bioactive compounds such as furanocoumarins and
flavonoids of important biological activities. An endophytic fungus was
isolated from the fruits and identified as Aspergillus amstelodami
(MK215708) by morphology, microscopical characterization, [...] Read
more.
(This article belongs to the Special Issue Antibiofilm Efficacy of
Natural and Natural-Based Products)
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16 pages, 5266 KiB
Open AccessArticle
Anti-Inflammatory Activities of Isogosferol, a Furanocoumarin Isolated
from Citrus junos Seed Shells through Bioactivity-Guided Fractionation
by Hwa Young Song, Ara Jo, Jihun Shin, Eui Hyeon Lim, Ye Eun Lee, Da Eun
Jeong and Mina Lee
Molecules 2019, 24(22), 4088;
https://doi.org/10.3390/molecules24224088- 12 Nov 2019
Cited by 17 | Viewed by 3043
Abstract Citrus junos Tanaka is a traditional medicine for treating
coughs, dyspepsia, diabetes, asthma, neuralgia, and inflammatory
disorders, and is distributed in Asia, especially in Korea, Japan, and
China. This study aimed to use bioactivity-guided fractionation to find
therapeutic phytochemicals from C. junos seeds, [...] Read more.
(This article belongs to the Section Natural Products Chemistry)
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11 pages, 1632 KiB
Open AccessArticle
Structural Insights into the Interaction of Cytochrome P450 3A4 with
Suicide Substrates: Mibefradil, Azamulin and 6′,7′-Dihydroxybergamottin
by Irina F. Sevrioukova
Int. J. Mol. Sci. 2019, 20(17), 4245;
https://doi.org/10.3390/ijms20174245 - 30 Aug 2019
Cited by 17 | Viewed by 4314
Abstract Human cytochrome P450 3A4 (CYP3A4) is the most important
drug-metabolizing enzyme. Some drugs and natural compounds can act as
suicide (mechanism-based) inactivators of CYP3A4, leading to
unanticipated drug-drug interactions, toxicity and therapeutic failures.
Despite significant clinical and toxicological implications, the
mechanism-based inactivation remains [...] Read more.
(This article belongs to the Special Issue Cytochromes P450: Drug
Metabolism, Bioactivation and Biodiversity 2.0)
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39 pages, 1169 KiB
Open AccessReview
Apium Plants: Beyond Simple Food and Phytopharmacological Applications
by Bahare Salehi, Alessandro Venditti, Claudio Frezza, Aysun Yücetepe,
Ümit Altuntaş, Sibel Uluata, Monica Butnariu, Ioan Sarac, Shabnum
Shaheen, Spyridon A. Petropoulos, Karl R. Matthews, Ceyda Sibel Kılıç,
Maria Atanassova, Charles Oluwaseun Adetunji, Adedayo Oluwaseun
Ademiluyi, Beraat Özçelik, Patrick Valere Tsouh Fokou, Natália Martins,
William C. Cho and Javad Sharifi-Rad
Appl. Sci. 2019, 9(17), 3547;
https://doi.org/10.3390/app9173547 - 29
Aug 2019
Cited by 30 | Viewed by 13454
Abstract Apium plants belong to the Apiaceae family and are included
among plants that have been in use in traditional medicine for thousands
of years worldwide, including in the Mediterranean, as well as the
tropical and subtropical regions of Asia and Africa. Some highlighted
[...] Read more.
(This article belongs to the Special Issue New bioactive Molecules:
Challenges in Environmental and Nutritional Health)
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25 pages, 2798 KiB
Open AccessFeature PaperReview
Botanical Sources, Chemistry, Analysis, and Biological Activity of
Furanocoumarins of Pharmaceutical Interest
by Renato Bruni, Davide Barreca, Michele Protti, Virginia Brighenti,
Laura Righetti, Lisa Anceschi, Laura Mercolini, Stefania Benvenuti,
Giuseppe Gattuso and Federica Pellati
Molecules 2019, 24(11), 2163;
https://doi.org/10.3390/molecules24112163- 8 Jun 2019
Cited by 85 | Viewed by 9260
Abstract The aim of this work is to provide a critical review of plant
furanocoumarins from different points of view, including their chemistry
and biosynthetic pathways to their extraction, analysis, and synthesis,
to the main biological activities found for these active compounds, in
order [...] Read more.
(This article belongs to the Special Issue Coumarins and Coumarin
Derivatives: From Chemistry to Drug)
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19 pages, 4064 KiB
Open AccessArticle
The Effect of Furanocoumarin Derivatives on Induction of Apoptosis and
Multidrug Resistance in Human Leukemic Cells
by Tomasz Kubrak, Marcin Czop, Przemysław Kołodziej, Marta Ziaja-Sołtys,
Jacek Bogucki, Anna Makuch-Kocka, David Aebisher, Janusz Kocki and Anna
Bogucka-Kocka
Molecules 2019, 24(9), 1824;
https://doi.org/10.3390/molecules24091824 -
12 May 2019
Cited by 11 | Viewed by 3512
Abstract Background: The insensitivity of cancer cells to therapeutic
agents is considered to be the main cause of failure of therapy and
mortality of patients with cancer. A particularly important problem in
these patients is the phenomenon of multidrug resistance, consisting of
abnormal, elevated [...] Read more.
(This article belongs to the Special Issue Coumarins and Coumarin
Derivatives: From Chemistry to Drug)
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9 pages, 555 KiB
Open AccessArticle
Assessment of Total Phenolic Content, In Vitro Antioxidant and
Antibacterial Activity of Ruta graveolens L. Extracts Obtained by
Choline Chloride Based Natural Deep Eutectic Solvents
by Valentina Pavić, Dora Flačer, Martina Jakovljević, Maja Molnar and
Stela Jokić
Plants 2019, 8(3), 69;
https://doi.org/10.3390/plants8030069 - 18 Mar
2019
Cited by 46 | Viewed by 5220
Abstract Rue (R. graveolens) has been an extensively studied medicinal
plant due to its rich phytochemicals content, such as furanocoumarins
and flavonoids. The aim of this study was to determine the effects of
varying extraction conditions on the total phenolic content, the [...]
Read more.
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13 pages, 913 KiB
Open AccessReview
Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in
Cancer Prevention and Therapy
by Jeong-Hyeon Ko, Frank Arfuso, Gautam Sethi and Kwang Seok Ahn
Int. J. Mol. Sci. 2018, 19(12), 4048;
https://doi.org/10.3390/ijms19124048 - 14 Dec 2018
Cited by 34 | Viewed by 6233
Abstract Cancer still remains one of the leading causes of death
worldwide. In spite of significant advances in treatment options and the
advent of novel targeted therapies, there still remains an unmet need
for the identification of novel pharmacological agents for cancer
therapy. This [...] Read more.
(This article belongs to the Special Issue Feature Annual Reviews in
Molecular Sciences 2019)
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13 pages, 1214 KiB
Open AccessArticle
Preparation, Characterization, and Pharmacokinetic Evaluation of
Imperatorin Lipid Microspheres and Their Effect on the Proliferation of
MDA-MB-231 Cells
by Xinli Liang, Xulong Chen, Guowei Zhao, Tao Tang, Wei Dong, Chunyan
Wang, Jing Zhang and Zhenggen Liao
Pharmaceutics 2018, 10(4), 236;
https://doi.org/10.3390/pharmaceutics10040236 - 16 Nov 2018
Cited by 7 | Viewed by 3721
Abstract Imperatorin is a chemical compound belonging to the linear
furanocoumarins. Imperatorin is attracting considerable attention
because of its antitumor, antibacterial, anti-inflammatory, and
anticoagulant activities, inhibition of myocardial hypertrophy, and
other pharmacological efficacies. However, imperatorin has limited water
solubility and has better lipid solubility; [...] Read more.
(This article belongs to the Special Issue Functional Nanohybrids for
Drug Delivery)
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11 pages, 1785 KiB
Open AccessFeature PaperArticle
Bergamottin Suppresses Metastasis of Lung Cancer Cells through
Abrogation of Diverse Oncogenic Signaling Cascades and
Epithelial-to-Mesenchymal Transition
by Jeong-Hyeon Ko, Dongwoo Nam, Jae-Young Um, Sang Hoon Jung, Gautam
Sethi and Kwang Seok Ahn
Molecules 2018, 23(7), 1601;
https://doi.org/10.3390/molecules23071601 -
2 Jul 2018
Cited by 71 | Viewed by 3789
Abstract Bergamottin (BGM) is a naturally occurring furanocoumarin and
is known to inhibit the growth of tumor cells. However, there is no
available evidence that BGM has an inhibitory effect on cancer
metastasis, specifically on the epithelial-to-mesenchymal transition
(EMT) process in the malignant cells. [...] Read more.
(This article belongs to the Section Natural Products Chemistry)
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136 KiB
Open AccessAbstract
Screening of Some Apiaceae and Asteraceae Plants for Their Cytotoxic
Potential
by Perihan Gürbüz, Kübra Uzun, Ebru Öztürk and Mükerrem Betül Yerer
Proceedings 2017, 1(10), 1004;
https://doi.org/10.3390/proceedings1101004 - 13 Nov 2017
Cited by 1 | Viewed by 2046
Abstract Terpenoids, especially sesquiterpene lactones (SLS) and
furanocoumarins are diverse secondary metabolite groups which show a
promising efficiency on different cancer cell lines. Therefore the
screening of terpenoid and/or coumarin rich palnts from the plant
kingdom remains still importance. Breast cancer and lung adenocarcinoma
[...] Read more.
(This article belongs to the Proceedings of Proceedings of the 2nd
International Conference on Natural Products for Cancer Prevention and
Therapy)
1341 KiB
Open AccessArticle
Design, Synthesis and Antifungal Activity of Psoralen Derivatives
by Xiang Yu, Ya Wen, Chao-Gen Liang, Jia Liu, Yu-Bin Ding and Wei-Hua
Zhang
Molecules 2017, 22(10), 1672;
https://doi.org/10.3390/molecules22101672- 9 Oct 2017
Cited by 23 | Viewed by 5402
Abstract A series of linear furanocoumarins with different substituents
have been designed and synthesized. Their structures were confirmed by
1H-NMR spectroscopy, high resolution mass spectra (EI-MS), IR, and X-ray
single-crystal diffraction. All of the target compounds were evaluated
in vitro for their antifungal [...] Read more.
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1656 KiB
Open AccessArticle
Characterization and Purification of Bergamottin from Citrus grandis
(L.) Osbeck cv. Yongjiazaoxiangyou and Its Antiproliferative Activity
and Effect on Glucose Consumption in HepG2 cells
by Yilong Liu, Chuanhong Ren, Yunlin Cao, Yue Wang, Wenyi Duan, Linfeng
Xie, Chongde Sun and Xian Li
Molecules 2017, 22(7), 1227;
https://doi.org/10.3390/molecules22071227 -
20 Jul 2017
Cited by 30 | Viewed by 5479
Abstract Bergamottin is a natural furanocoumarin compound with weak
polarity. Characterization and quantification of bergamottin were
carried out in different fruit tissues of various citrus cultivars.
Among the four citrus tissues tested, i.e., flavedo, albedo, segment
membrane (SM), and juice sacs (JS) in eight [...] Read more.
(This article belongs to the Section Natural Products Chemistry)
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1905 KiB
Open AccessArticle
Simultaneous Determination of Three Furanocoumarins by UPLC/MS/MS:
Application to Pharmacokinetic Study of Angelica dahurica Radix after
Oral Administration to Normal and Experimental Colitis-Induced Rats
by Youn-Hwan Hwang, Hye Jin Yang and Jin Yeul Ma
Molecules 2017, 22(3), 416;
https://doi.org/10.3390/molecules22030416 -
7 Mar 2017
Cited by 17 | Viewed by 4973
Abstract In traditional oriental medicine, Angelica dahurica Radix (ADR)
is used in the treatment of gastrointestinal, respiratory,
neuromuscular, and dermal disorders. We evaluated the pharmacokinetic
profiles of oxypeucedanin, imperatorin, and isoimperatorin, major active
ingredients of ADR, in normal and 2,4,6-trinitrobenzene sulfonic acid
(TNBS)-induced colitis [...] Read more.
(This article belongs to the Section Natural Products Chemistry)
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514 KiB
Open AccessArticle
Simultaneous Quantification of Nine New Furanocoumarins in Angelicae
Dahuricae Radix Using Ultra-Fast Liquid Chromatography with Tandem Mass
Spectrometry
by Lei Zhang, Wei Wei and Xiu-Wei Yang
Molecules 2017, 22(2), 322;
https://doi.org/10.3390/molecules22020322 -
20 Feb 2017
Cited by 10 | Viewed by 5273
Abstract A series of new furanocoumarins with long-chain hydrophobic
groups, namely andafocoumarins A–H and J, have been isolated from the
dried roots of Angelica dahurica cv. Hangbaizhi (Angelicae Dahuricae
radix) in our previous study, among which andafocoumarins A and B were
demonstrated to have [...] Read more.
(This article belongs to the Collection Bioactive Compounds)
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1641 KiB
Open AccessArticle
A Method for LC-MS/MS Profiling of Coumarins in Zanthoxylum
zanthoxyloides (Lam.) B. Zepernich and Timler Extracts and Essential
Oils
by Yoro Tine, Franck Renucci, Jean Costa, Alassane Wélé and Julien
Paolini
Molecules 2017, 22(1), 174;
https://doi.org/10.3390/molecules22010174 -
22 Jan 2017
Cited by 43 | Viewed by 9712
Abstract The metabolites from the coumarin class, present in tissues of
plants belonging mainly to the Rutaceae and Apiaceae families, included
compounds with high chemical diversity such as simple coumarins and
furocoumarins. These health-promoting components are recognized for
their valuable biological activities in herbal [...] Read more.
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389 KiB
Open AccessArticle
Identification of Nematicidal Constituents of Notopterygium incisum
Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita
by Gai Liu, Daowan Lai, Qi Zhi Liu, Ligang Zhou and Zhi Long Liu
Molecules 2016, 21(10), 1276;
https://doi.org/10.3390/molecules21101276- 23 Sep 2016
Cited by 36 | Viewed by 6128
Abstract During a screening program for new agrochemicals from Chinese
medicinal herbs, the ethanol extract of Notopterygium incisum rhizomes
was found to possess strong nematicidal activity against the two species
of nematodes, Bursaphelenchus xylophilus and Meloidogyne incognita.
Based on bioactivity-guided fractionation, the four [...] Read more.
(This article belongs to the Section Natural Products Chemistry)
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1766 KiB
Open AccessArticle
Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with
Multidrug Resistance Reversal and Anti-Inflammatory Activities
by Jun Lee, You Jin Lee, Jinhee Kim and Ok-Sun Bang
Molecules 2015, 20(12), 20967-20978;
https://doi.org/10.3390/molecules201219738 - 25 Nov 2015
Cited by 44 | Viewed by 6787
Abstract In the search for novel herbal-based anticancer agents, we
isolated a new angular-type pyranocoumarin,
(+)-cis-(3′S,4′S)-3′-angeloyl-4′-tigloylkhellactone (1) along with 12
pyranocoumarins (2–13), two furanocoumarins (14, 15), and a
polyacetylene [...] Read more.
(This article belongs to the Collection Bioactive Compounds)
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1262 KiB
Open AccessArticle
Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste
Receptors and TRP Channels Involved in Gustation and Nociception
by Giuseppe Mancuso, Gigliola Borgonovo, Leonardo Scaglioni and Angela
Bassoli
Molecules 2015, 20(10), 18907-18922;
https://doi.org/10.3390/molecules201018907 - 16 Oct 2015
Cited by 33 | Viewed by 9443
Abstract Ruta graveolens (rue) is a spontaneous plant in the
Mediterranean area with a strong aroma and a very intense bitter taste,
used in gastronomy and in folk medicine. From the leaves, stems and
fruits of rue, we isolated rutin, rutamarin, three furanocoumarins, two
[...] Read more.
(This article belongs to the Collection Phytochemicals: Biosynthesis,
Metabolism and Biological Activities)
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669 KiB
Open AccessArticle
Cytotoxic Activity and Composition of Petroleum Ether Extract from
Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)
by Giuseppina Autore, Stefania Marzocco, Carmen Formisano, Maurizio
Bruno, Sergio Rosselli, Mariem Ben Jemia and Felice Senatore
Molecules 2015, 20(1), 1571-1578;
https://doi.org/10.3390/molecules20011571 - 16 Jan 2015
Cited by 30 | Viewed by 9176
Abstract The petroleum ether extract of Magydaris tomentosa flowers
(Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly
constituted by furanocoumarins such as xanthotoxin, xanthotoxol,
isopimpinellin, and bergaptene. Other coumarins such as
7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also
occurred. The antiproliferative [...] Read more.
(This article belongs to the Collection Bioactive Compounds)
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225 KiB
Open AccessArticle
Triterpene Esters: Natural Products from Dorstenia arifolia (Moraceae)
by Catharina E. Fingolo, Thabata De S. Santos, Marcelo D. M. Vianna
Filho and Maria Auxiliadora C. Kaplan
Molecules 2013, 18(4), 4247-4256;
https://doi.org/10.3390/molecules18044247 - 11 Apr 2013
Cited by 49 | Viewed by 8414
Abstract The phytochemical study of Dorstenia arifolia Lam. (Moraceae)
has led to the identification of 18 triterpenes esterified by fatty
acids, five triterpenes without esterification, 12 triterpenes
esterified by acetic acid, together with a known furanocoumarin:
α-amyrin (1), β-amyrin (2) [...] Read more.
(This article belongs to the Special Issue Triterpenes and Triterpenoids
2013)
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185 KiB
Open AccessArticle
Antimycobacterial Activity of Constituents from Foeniculum vulgare Var.
Dulce Grown in Mexico
by Patricia C. Esquivel-Ferriño, Juan Manuel J. Favela-Hernández, Elvira
Garza-González, Noemí Waksman, María Yolanda Ríos and María del Rayo
Camacho-Corona
Molecules 2012, 17(7), 8471-8482;
https://doi.org/10.3390/molecules17078471 - 13 Jul 2012
Cited by 57 | Viewed by 6999
Abstract Bioassay guided fractionation of an antimycobacterial extract
of Foeniculum vulgare var dulce (Apiaceae) led to the isolation and
characterization of 5-hydroxyfurano-coumarin. The chemical structure of
this compound was elucidated by 1H and 13C (1D and 2D) Nuclear Magnetic
Resonance (NMR) spectroscopy. [...] Read more.
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331 KiB
Open AccessArticle
The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis
Factor-Related Apoptosis-Inducing Ligand (TRAIL)
by Joanna Bronikowska, Ewelina Szliszka, Dagmara Jaworska, Zenon P.
Czuba and Wojciech Krol
Molecules 2012, 17(6), 6449-6464;
https://doi.org/10.3390/molecules17066449 - 29 May 2012
Cited by 82 | Viewed by 7818
Abstract Coumarins are a very common type of secondary plant metabolites
with a broad spectrum of biological activities. Psoralidin is a
naturally occurring furanocoumarin isolated from Psoralea corylifolia
possessing anticancer and chemopreventive properties. Tumor necrosis
factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in
cancer cells [...] Read more.
(This article belongs to the Collection Bioactive Compounds)
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249 KiB
Open AccessArticle
Pressurized Liquid Extraction of Coumarins from Fruits of Heracleum
leskowii with Application of Solvents with Different Polarity under
Increasing Temperature
by Krystyna Skalicka-Woźniak and Kazimierz Głowniak
Molecules 2012, 17(4), 4133-4141;
https://doi.org/10.3390/molecules17044133 - 5 Apr 2012
Cited by 31 | Viewed by 8330
Abstract Coumarins are nowadays an important group of organic compounds
from natural sources that are useful in a number of fields. Because they
possess different pharmacological properties, finding the proper
extraction conditions for their separation from plant matrices is a very
important step. In [...] Read more.
(This article belongs to the Special Issue Coumarins and Xanthones)
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326 KiB
Open AccessArticle
Evaluation of Flavonoids and Furanocoumarins from Citrus bergamia
(Bergamot) Juice and Identification of New Compounds
by Claudio Gardana, Federico Nalin and Paolo Simonetti
Molecules 2008, 13(9), 2220-2228;
https://doi.org/10.3390/molecules13092220 - 18 Sep 2008
Cited by 47 | Viewed by 20548
Abstract Bergamot juice (BJ) contains different classes of flavonoids
(e.g. flavanones and flavones) that can exert beneficial effects on
human health. The aim of this study was to evaluate the qualitative and
quantitative composition of a BJ obtained from fruits harvested in
Southern Italy [...] Read more.
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Anti-cancer furanocoumarines - kompendium wiedzy dla lekarzy i znachorów
Re: Anti-cancer furanocoumarines - kompendium wiedzy dla lekarzy i znachorów