Re: AI constructing functional genomes

On 11/16/2024 3:53 PM, erik simpson wrote:

On 11/16/24 1:41 PM, RonO wrote:

https://www.science.org/content/article/meet-evo-dna-trained-ai- creates-genomes-scratch
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Some researchers have developed a program that will construct functional genomes.  That is the hype claim of this Science news article.
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The program supposedly can predict what amino acid changes for a protein will do to it's function, so it could produce a lifeform with the phenotype that it wanted to create.
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They claim that they did not use any human pathogens to train their AI, so that terrorists should not be able to use it to construct bio weapons.
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The current program is for bacteria.  If they produce a similar program for vertebrates we could use it to predict the phenotypic change of amino acid substitutions in livestock species and for diagnosis of human genetic diseases.  It could lead to diagnosis for humans and for gene editing targets for breeding animals.
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The researchers claim their goals are to study evolution of life forms.
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Ron Okimoto
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Learning which gene are expressed where is one thing.  Being able to predict what changes would happen if you tweak them is a whole nother
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 They claim that they can make that prediction.  There is already an AI program that can determine the structure of a protein based on it's amino acid sequence.  They likely combined that with functional data.
 Ron Okimoto