Sujet : Junk DNA fraction and mutational load
De : me22over7 (at) *nospam* gmail.com (MarkE)
Groupes : talk.originsDate : 28. Jan 2025, 08:25:40
Autres entêtes
Organisation : A noiseless patient Spider
Message-ID : <vna0pk$1lk94$1@dont-email.me>
User-Agent : Mozilla Thunderbird
Dan Graur has argued that for purifying selection to prevent mutational load runaway, the functional fraction of the genome must be constrained (to 10-15%?).
If the mutation rate was halved, would the allowable functional fraction double? Or is it not that simple?
I posted a comment on Sandwalk criticising the latest Long Story Short video's treatment of the c-value paradox:
https://sandwalk.blogspot.com/2025/01/intelligent-design-creationists-launch.htmlI also posted a query on this paper which argues against Graur's conclusion: "Mutational Load and the Functional Fraction of the Human Genome"
https://academic.oup.com/gbe/article/12/4/273/5762616?login=falseLarry Moran responded with "Graur refereed that paper and he now agrees with the general conclusion that the mutation load argument does not put a severe constraint on the fraction of functional DNA in the human genome."
Is this now generally accepted?
Note though the paper referenced has this conclusion: "We stress that we, in this work, take no position on the actual proportion of the human genome that is likely to be functional. It may indeed be quite low, as the contemporary evidence from species divergence and intraspecies polymorphism data suggests. Many of the criticisms of the ENCODE claim of 80% functionality (e.g., Doolittle 2013; Graur 2013) strike us as well founded. Our conclusion is simply that an argument from mutational load does not appear to be particularly limiting on f."