Sujet : Nature news article on the BC bird flu infection
De : rokimoto557 (at) *nospam* gmail.com (RonO)
Groupes : talk.originsDate : 22. Nov 2024, 19:07:23
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Organisation : A noiseless patient Spider
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https://www.nature.com/articles/d41586-024-03805-4The teen patient is in critical condition. The Canadian patient is not infected by the dairy virus, but an H5N1 strain circulating in migratory fowl. The troubling thing is that this infection may be so severe for the patient because the virus has two mutations that may facilitate human respiratory infection. The wild avian virus does not have these two mutations, and the proposal is that the virus may have mutated during the infection of the teen and turned the virus into something more of a problem for human infection. Essentially, the patient's cells selected for these new mutations and allowed rapid amplification. It sounds like they are hoping that this variant is not circulating out in the wild, and that it evolved in this patient.
The dairy virus is a recombinant with a North American strain of avian influenza. It retains the H5N1 genes of the Asian H5N1 virus, but half of it's genome is from another virus. The virus that infected this teen may not be a recombinant. I can't find anywhere that defines what this version of the virus is. The Asian H5N1 influenza virus had a 50% mortality rate when infecting humans. The Dairy virus only exhibits mild symptoms, so far, but this patient is in critical condition. If the Canadian variant is circulating among wild birds with the two facilitating mutations it may be worse news than the dairy virus.
Ron Okimoto