Re: NIH is claiming to do something different with the dairy virus

On 1/2/2025 3:41 PM, RonO wrote:

On 1/1/2025 2:52 PM, RonO wrote:

https://www.nih.gov/news-events/news-releases/nih-officials-assess- threat-h5n1
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Published Dec 31.
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In a commentary published in the New England Journal of Medicine, NIAID Director Jeanne M. Marrazzo, M.D., M.P.H., and Michael G. Ison, M.D., M.S., chief of the Respiratory Diseases Branch in NIAID’s Division of Microbiology and Infectious Diseases, say people should find a balance between enhanced vigilance and “business as usual” with respect to HPAI H5N1.
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This is an indirect way of stating that the CDC and USDA haven't been doing their jobs.
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QUOTE:
Against this backdrop, Drs. Marrazzo and Ison say there are four keys to controlling the current outbreak. The first imperative is timely, effective collaborations among investigators in human and veterinary medicine, public health, health care, and occupational workers, such as dairy and poultry workers.
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This involves cultivating trust not only between numerous entities, but with people seeking care for symptoms of concern, including conjunctivitis, the authors write. Fortunately, so far most U.S. cases of HPAI H5N1 have been mild and resolved on their own without the need for treatment.
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This has not happened, and it is fortunate that the human cases have been mild.  The CDC still has not put out any information on their human dairy worker testing that they were supposed to start in early Nov, and California initally claimed that they were going to start a worker testing program early in their infection, but that never happened and out of the 5,000 workers that they could have tested they only tested 130 after essentially quiting after their initial success with their first 39 tested.
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Their second key is a focus on the Canadian HPAI H5N1 patient, who developed respiratory failure and required life-saving medical intervention and treatment before recovering. The authors write that mutations found in the virus in this patient highlight an urgent need for vigilant disease surveillance to identify and assess viral changes to evaluate the risk for person-to-person transmission. Effective surveillance, they say, requires that complete genomic sequencing data from animals and people are made rapidly and readily available.
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Without information pertaining to where and when isolates were collected, the data cannot be linked phylogenetically to other reported sequences, limiting insight into how the virus is spreading, they write. These data would also provide opportunity for early detection of mutations that might portend avidity for human respiratory epithelium, which may require as little as one mutation in the virus.
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Even the NIH needs to differentiate the D1.1 genotype from the B3.13 dairy genotype.  The Canadian and Louisiana patients both with severe symptoms were genotype D1.1.  In both cases the D1.1 genotype had the same mutations that were not found in the local virus in birds, so they claimed that these mutations that, apparently made the infections more severe had occurred within each patient independently.  The D1.1 genotype should be tracked more diligently than the Dairy virus.  This is also the virus that they need to be checking the efficacy of the current H5 vaccine strain on.
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This seems to be a direct rebuke of the current policy of not releasing the conclusions of the sequencing efforts.  The last half month there has been suppression of the results.  The cat infection case in Oregon had been sequenced and they knew that the sequence was identical in the dead cat and in the pet food that the cat ate, but they would not state if it was the dairy virus or not.  The same goes for the Washington big cat cases and California cat cases, and also the Wisconsin poultry worker.  A phylogeny and epidemiological sequence analysis has not been done since early in the infection when they determined that some infected states had not gotten infected cattle, but had obviously been infected from Texas.  They refused to start testing dairy workers that had likely taken the virus to other states that did not get cattle. They could tell which farms in Texas had the most closely related virus sequence, but never initiated contact tracing between those farms and the states with infected dairies.
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The Colorado virus was found to be most closely related to the virus that had infected a Michigan dairy worker, so there wasn't much doubt as to how Colorado got infected with a Michigan strain, and they should not have gotten Michigan Cattle.
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The USDA is still not releasing the sequence information so that it can be effectively used to trace the spread of the infection.  They just give the sample submission date, date of sequencing, and claim the location is the USA.  This was determined to be inadequate with the first epidemiological sequence analysis, but the USDA never changed, and kept putting out nearly worthless sequence information.  Before I retired I contacted the USDA avain lab in Georgia and asked for the contact information for the USDA researchers that were responsible for putting out the sequence data, so that I could get more information about the sequences that those researchers obviously would have.  I was told that they did not give out that information.  The USDA should have been doing a weekly epidemiological sequence analysis from the beginning of the infection, but that has never been initiated (or the results have been suppressed) and researchers that are willing to do it, can't do it because of the nearly worthless way in which the sequence is annotated.
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Third, researchers must continue to develop and test medical countermeasures—such as vaccines and therapies that eliminate or alleviate disease—against H5N1 and other influenza viruses. Fortunately, current vaccine candidates neutralize the circulating strains, which so far are susceptible to antivirals that could mitigate transmission and severity of illness, they write.
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Lastly, Drs. Marrazzo and Ison encourage people to take precautions to prevent exposure to the virus and minimize the risk of infection. For example, people who work with poultry and cows should use personal protective equipment and educate themselves about occupational risks when working with birds and mammals, as CDC and USDA have repeatedly recommended.
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They are testing countermeasures, but so what?  The statement about current vaccine efficacy is dated.  The virus tested was isolated from a dairy worker at the beginning of the dairy infection (March 2024), and was found to be neutralized by the then vaccine H5 antigen.  The virus has since mutated, and the CDC found that they had to make a synthetic H5 antigen with the Missouri amino acid substitutions in it in order to detect neutralizing antibodies in the Missouri patient's blood (Oct 2024) and still 2 of the three antibody tests failed.  The current vaccine strain of H5, likely has lost efficacy against the current virus.  The California virus is also supposed to have multiple amino acid substitutions in the H5 gene.
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A recent news article that I put up claimed that some infected dairies in California were not using personal protective equipment to protect their dairy workers.  It is only a "recommendation" by the USDA and CDC, just as it was voluntary (and still is in most states) to test your herd for infection.  Workers were only "recommended" to not go to other farms if they worked with infected animals and that obviously was not enforced even in California when they knew that the workers were likely spreading the virus.  All the infected dairies and poultry farms in California is a testament to the fact that the denial of workers transmitting the virus should have been dealt with long ago when the USDA determined that it was likely worker transmission to poultry farms and other dairies in Michigan back in June.
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Since they never wanted to identify all the infected herds even their "recommendations" did not have to be followed on farms that would not admit to being infected, and refused to be tested.  So workers have been freely infected since the start of the dairy epidemic, probably, on most of the infected farms because most of the infected farms, likely never were determined to be infected. In states where infected herds were searched for like Colorado and California more than 60% of the herds in those states were found to be infected.  That should tell you how sad the response has been in all the other states with known infected herds, and even states like Florida and Washington that have had infected poultry flocks, but refused to test their dairy herds.
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Ron Okimoto
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https://www.cidrap.umn.edu/avian-influenza-bird-flu/california-probe- ties-cats-avian-flu-illness-raw-pet-food
 http://publichealth.lacounty.gov/phcommon/public/media/ mediapubdetail.cfm? unit=media&ou=ph&prog=media&resultyear=2024&prid=4923&row=25&start=1
 The stupid denial and suppression of conclusions continues.  The articles above admit that the cat died from eating raw pet food and that the cat had the same virus as found in the pet food, but like the Oregon, Washington, and other California cases they refuse to identify the dairy virus as being the infective agent.
 It is stupid that they refuse to note that the dairy worker verified to be infected in Southern California was obviously infected with the dairy virus.
 Instead they have started to call the virus the "H5 bird flu".  This is a stupid cover up of their failure to contain the dairy virus.
 The CIDRAP article notes how many birds have been affected since 1922 without acknowledging that most of the infected poultry in 2024 have been infected by the dairy virus even in states like Washington and Florida that will not admit that they have infected dairy herds.
 Yes, poultry infections have increased late in 2024, but most of those flocks were infected by the dairy virus.  They are trying to blame wild birds, but that is just stupid.  It is the D1.1 genotype that is widespread among wild birds, and the B3.13 genotype that is in wild birds (not found on dairies) is very different in sequence of the H5 and N1 genes than the B3.13 genotype infecting dairy herds.
 They just need to admit that they screwed up by letting the dairy virus spread to the extent that it has, and that it is now getting into the food supply.  The pet food is made of by-products of meat processed for human consumption.
 Ron Okimoto
 

Wisconsin is putting out information telling people working with dairy cattle that they should take precautions against avian influenza.  The CDC and Wisconsin will not admit that the poultry worker was infected with the dairy virus, and Wisconsin is a major dairy state.  It is not on the initial list for testing, but the USDA has also directed that all states must inform them of positive dairy herds.  If they don't test, they have nothing to tell the USDA.
https://publichealthmdc.com/blog/2025-01-06/bird-flu-101-what-to-know-about-the-current-outbreak
Wisconsin has been in denial of having the dairy virus for months. Michigan, Minnesota, and Iowa have infected herds by August and September, but Wisconsin has never admitted to having infected herds. At this time they seem to be waiting to be forced to detect their infected herds.  At this time they should be doing more than recommending that dairy workers should be protected.
https://www.aphis.usda.gov/sites/default/files/20241206-aphis-nmts-public-info.508.pdf
The USDA claimed that they were going to start testing all the dairies in states with known infected herds back in Nov.  They were supposed to have started within 30 days, but that never happened.  In December they announced the program linked to above, and claimed that they were going to start testing with half a dozen states (some had not admitted to having infected herds, but were not likely candidates like Washington and Florida that have had poultry flocks go down with the dairy virus. A week or so later they added half a dozen more states when Oregon had an infected poultry flock.  Neither Washington nor Oregon has started testing their herds.
It is just sad that there is still no results from the USDA Silo study announced the first week of December.  The plan is to eventually test all states, but they can't seem to get started.  Wisconsin has likely been infected for so long that most of the dairies in the state have likely been infected and a lot of them have likely recovered as the virus has burned through the dairies.  By the time the USDA gets around to testing Wisconsin all the dairies may have already been infected, and most of them would have recovered.  In 3 months over 70% of the dairies in California have been infected, and 56 of the first infected dairies have already tested virus free.  A lot of dairy workers have been infected in California, but they stopped testing the Dairy workers after only testing 130 (36 were found to be infected, 27%).  They claim over 5,000 dairy workers associated with the infected farms.  The CDC claimed that they were going to start a Dairy worker testing program in October, but announced another start in Nov. and they still have not produced any results.  The CDC did OK a commercial test for the dairy virus during this time, but as stupid as it may be the test is a nasal swab test and most of the infected dairy workers have been negative for nasal swabs, but positive for eye tests.  The virus infects the eye, my guess is that the tear ducts have the same receptors that cattle mammary glands have. This seems to be worse than simple stupidity, but an effort to not identify most of the infected.
Ron Okimoto